A new diagnostic kit which takes the uncertainty out of lymphoma diagnosis, has been launched at the Veterinary Cancer Society’s annual conference this month.
Developed by PetScreen in the UK, the announcement is a significant breakthrough in the diagnosis of canine lymphoma with the major benefit being that it is able to differentiate between patients with lymphadenopathy due to lymphoma and lymphadenopathy due to other ailments such as lymphoid hyperplasia.
The announcement also signals a partnership and commercial venture between PetScreen Ltd and Tridelta Development Ltd to jointly develop manufacture and market a unique range of veterinary cancer diagnostic kits under the banner of ‘Tri-Screen’ (http://www.tri-screen.net). PetScreen has established the first reference laboratory offering the Advanced Lymphoma Blood Test (ALBT) utilising the Tri-Screen Canine Lymphoma assay kit. The kit is available now to enable laboratories worldwide to offer veterinarians this advanced testing system.
For the past two years, PetScreen’s research team have been busy characterising and identifying the biomarkers used in their earlier lymphoma blood test. They found that two of the markers are Acute Phase Proteins (APP’s). Although APP’s have been investigated in veterinary medicine for some time PetScreen has developed a unique multi-marker approach which led to the development of patented and copyrighted analytical algorithms which combine the relative values of both Haptoglobin and C-Reactive Protein (CRP) in serum.
By enlisting the support of vets in the UK and USA the assay has been rigorously tested with 194 canine patients with lymphoma, benign lymphoid hyperplasia and other diseases with similar presentation to lymphoma as well as healthy dogs.
By testing the acute phase proteins using immunoassay, PetScreen achieved excellent levels of high performance, reproducibility and objectivity. The combination of the three diagnostic elements enables differentiation with a very high degree of sensitivity and specificity … ensuring an appropriate treatment regimen can begin at a critical early stage of disease identification and development.
In order to make this available to a global reference laboratory market, a partner with a unique understanding of APP diagnostic kit manufacture and marketing was required … it quickly became apparent that Tridelta’s reputation and experience with the international pharmaceutical industry in this niche sector qualified their preferred partner status. Each company brings its own strengths to the Tri-Screen brand of diagnostic kits. For Tridelta it is an important step into the companion animal marketplace; for PetScreen, the opportunity to globalise and advance their veterinary diagnostics expertise in this important and rapidly emerging sector.
Cancer in pets is more common than you think. It is the number one natural cause of death in geriatric cats and dogs and accounts for nearly 50 percent of pet deaths each year. Some breeds are especially susceptible to cancer.
What Causes Cancer in Dogs?
Although the leading cause of death in older cats and dogs, cancer also is the most treatable disease when compared to life-limiting diseases such as congestive heart failure, renal failure and diabetes. An educated and dedicated veterinary health care team is essential to caring for cancer-stricken pets.
“It is crucial for pet owners to take their pets to the veterinarian twice a year to monitor them for early signs of the disease,” says Dr. Gregory Ogilvie, a California Veterinary Medical Association member, world-renowned oncologist and director of the California Veterinary Specialists (CVS) Angel Care Cancer Center in Carlsbad, California. “Routine blood tests also can help identify problems early.”
Symptoms of Cancer in Dogs
Commons signs of cancer for pet owners to watch for include:
– Unexplained bleeding or discharge
– Loss of appetite
– Oral odor
– Abnormal swellings or swollen lymph nodes
– Drooling or difficulty eating or swallowing
– Changes in exercise or stamina level
– A sore that does not heal
– Chronic weight loss
– Change in bowel or bladder habits
The best treatment for cancer is prevention. Dr. Ogilvie recommends feeding cats and dogs a high-quality, balanced diet with low amounts of simple carbohydrates and high amounts of n-3 polyunsaturated fatty acids. He also advises pet owners to ensure their pets exercise regularly and eliminate pets’ exposure to industrial chemicals and tobacco smoke. Talk to your veterinarian to determine what’s best for your pet.
If your pet is diagnosed with cancer, there is hope. Advances in veterinary medicine and technology offer multiple treatment options, including chemotherapy, radiation and surgical procedures. Above all, enhancing your pet’s health, well-being and quality of life is the ultimate goal.
Cancer in Dogs – A Guide to Dealing With Canine Cancer
in association with our friends at Pet Screen
What’s good for us is good for our pets!
It is a sad fact that cancer amongst dogs is growing at an alarming rate. One of the big difficulties with animal cancer is that your pet cannot tell you when a cancer is developing, but if cancers can be detected early enough they respond well to treatment. With the introduction of new treatments, many cancers new respond better than ever.
Over recent years we have all become aware of the risk factors for human cancer. Responding to these by changing our habits is having a significant impact on our health. For example, stopping smoking, protection from excessive exposure to bright sunlight and eating a healthy diet high in fruit and vegetables all help to reduce cancer rates.
Another very important area is to keep a close eye on ourselves, going for regular health checks and reporting any lumps and bumps to our doctors as soon as they appear. Increased cancer awareness is without doubt improving human health.
Responding to risk factors will help reduce incidence. Being vigilant about any changes to our bodies will ensure that cancer is detected early. This will improve the chances of successful treatment. If we can do this for ourselves, we owe it to our pets to show similar care and attention.
Know your dog, keep an eye on the signs.
Approximately 25% of dogs will now die of cancer. Although this is a very alarming statistic, a positive diagnosis of cancer should not be seen as a death sentence. Cancer can be treated, and in many cases it can be cured. The success of treatment will depend on the type of cancer, the treatment used and on how early the tumour is found. The sooner treatment begins, the greater the chances of success. Therefore, one of the best things you can do for your dog is to keep a close eye on them for signs of the disease. This shouldn’t be an onerous task, it can be done as a part of everyday play and pampering.
10 Symptoms of Cancer in Dogs
1. Abnormal swellings or lumps that persist or continue to grow
2. Sores that do not heal
3. Loss of appetite
4. Weight loss
5. Bleeding or discharge from any body opening
6. Difficulty eating or swallowing
7. Offensive odour
8. Hesitation to exercise or loss of stamina
9. Persistent lameness or stiffness
10. Difficulty breathing, urinating, or defecating
If you spot any of these signs in your dog, you should report them to your vet as soon as possible. These symptoms often develop slowly, so it is best to get to know your dog’s habits well. It is also important to bear in mind that these symptoms can also be bought on by other diseases, so don’t immediately expect the worst.
Canine Cancer: Prognosis
Your vet will perform all the necessary diagnostic tests to discover the real cause of the problem. They may want to take an X ray, a blood test or a small sample of any growth (called a biopsy) for laboratory analysis. This information will be used to find out if the tumour is “benign” (which is a growth that can relatively easily be removed without any further complications) or “malignant” (which is a more aggressive tumour that invades tissues and can produce “secondary” growths known as metastasises).
Once your vet has made the diagnosis, they will discuss the various treatment options with you. As with human cancer treatment, these will be either surgery, radiotherapy or chemotherapy. Surgery is still the most widely used treatment for most dog cancers. In some cases a combination of treatments may be used. A combination of surgery followed by chemotherapy is used for some aggressive tumours. There are certain tumours, such as lymphoma (one of the most common malignancies in dogs), which are treated primarily by chemotherapy with very good results. Chemotherapy in dogs is not as unpleasant as it can be for humans.
Many owners worry that chemotherapy will cause their dog’s fur to fall out, this very rarely happens because the drugs attack the fast growing hairs on our heads but do not attack the slow growing coat on dogs. Whiskers, on the other hand, do grow fast, so don’t be alarmed if you dog looses few whiskers.
As cancer therapy becomes more sophisticated, there is increasing use of specialist referral centres where cancer specialists are able to provide the most advanced treatments available. Your vet will know the all the cancer referral centres and will advise you if they think one of these centres can offer better treatment for your dog.
Cancer treatment can be expensive, particularly for some of the more advanced treatments. However, the costs can be covered by pet insurance policies. If your dog is a high risk breed, taking out insurance will give you piece of mind to ensure that you give them the best treatment available, should the worst happen.
Some breeds are more prone than others.
It is unfortunate that some breeds have a higher incidence of cancer than others. It is difficult to provide a comprehensive list here, but the following is a brief guide:
Highest incidence breeds which also develop cancer at an earlier age than other dogs.
• Golden Retriever
• Bernese Mountain Dog
High incidence breeds
• Boston Terrier
• English Bulldog
• Scottish Terrier
• Cocker Spaniel
Average incidence breeds:
• Irish Setter
Relatively low incidence breeds:
The (near) future.
Research into better treatments for dog cancer is being conducted by the veterinary schools around the UK, specialist centres such as the Animal Health Trust and by pet health companies. The advances in biology are producing a steady flow of new treatments and tests which are now becoming available to improve cancer care.
At PetScreen we are developing new techniques to help spot cancer early and also to assist your vet in selecting the best possible treatment for your pet. To help us in this effort, we need small samples of tumour tissue and blood which are left over from your vet’s routine diagnostic tests. If you would like to help in this research effort by agreeing to donate samples which will be used to improve cancer care in the near future, please talk to your vet. If they could contact us on firstname.lastname@example.org, then we will contact them to discuss the details of sending the samples to our laboratory.
By working together we can help fight this disease.
[You are free to print this article and take it with you to your vet to discuss cancer screening for your pet]
Video Resources: Canine Cancer
Breast tumors can often occur in unspayed female dogs. Tumors are very often caused by hormonal imbalances and changes, together with a general state of toxemia and ill health. The breast tumor can be linked with an aestrogen factor.
What Are Tumors?
Tumors on any part of the body are the body’s attempt to localise and isolate some disease condition. “Tumor” means swelling, and tumors are benign or malignant by classification. In reality, a tumor is often benign in certain of its areas and malignant in others. Biopsies can aggravate the malignant portion of tumors, sometimes causing their rapid spreading.
Treatment for Breast Cancer in Dogs
By cutting out the tumor or tumors, one is only removing the local indications of the disease. Nothing is being done about the cause. In many cases the cause has not even been sought for or recognised.
Treatment Therapies for Canine Breast Cancer
Therapies that will decrease or dry up a tumor can also serve to prevent them. Nonorthodox treatments have been used to stop the spread, even though they did not significantly reduce the size of the tumor. It is the spread of a malignancy that kills, more often than the size of the tumor itself. Removing the toxic or poisonous quality is all-important in treating a tumor, malignant or otherwise.
Breast Cancer in Dogs: Diet
A diet rich in live, raw foods, will serve to supply vital enzymes to the body. Enzyme therapy may be indicated along with raw foods.
A theory on cancer that seems most valid among nutritional circles is that cancer is partly caused by faulty protein metabolisation. By changing to a raw, live-food diet, you will give the blood a chance to clarify itself. A clean blood stream means a healthy body. A diseased, choked-up blood stream can breed nothing but disease. Herbal therapies include blue violet leaves, red clover, goldenseal, garlic, and turnip used both internally and as a poultice; goose grass as a poultice; burdock, dandelion root, slippery elm, comfrey, blue flag, and poke root as a poultice and as tea.
According to K9 Magazine, dogs are at risk from the dangers of passive smoking.
Animal charity PDSA is quoted in K9 Magazine:
Wednesday 11 March is National No Smoking Day and as people across the country consider stubbing out once and for all, leading veterinary charity, PDSA, is encouraging owners to consider their pet’s health when lighting up.
Research* shows cats exposed to second-hand smoke are twice as likely to develop feline lymphoma, a potentially fatal form of cancer, in smoking households. It can also make them sneeze, cough and wheeze.
Dogs are also very susceptible to smoking-related respiratory problems and their exposure to tobacco smoke has been linked to nasal and sinus cancers**.
Cigarette smoke can also be extremely harmful to pet birds, which have very sensitive respiratory systems.
“The effects of passive smoking on humans are well known, but many people don’t realise their pets are also affected by breathing in second-hand smoke,” says PDSA Senior Veterinary Surgeon, Sean Wensley.